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US 6,280,957 B1Granted
Costimulatory blockade and mixed chimerism in allo-transplantation
AssigneeThe General Hospital Corporation
InventorsMohamed Sayegh, Megan Sykes
Life of this patent
Estimating the term…
Abstract
Use of the blockade of costimulation and hematopoietic stem cells in allograft transplantation.
Claims13
A method of promoting acceptance, by a recipient mammal, of a graft from a donor mammal of the same species comprising:
- administering to the recipient, an inhibitor of the CD40 ligand-CD40 costimulatory interaction;
- introducing into the recipient mammal, hematopoietic stem cells, and
- implanting the graft in the recipient.
Dependencies are inferred from the claim text.