Antibodies to bladder cancer nuclear matrix proteins and their use
AssigneeUniversity of Pittsburgh
InventorRobert H. Getzenberg
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Abstract
Nuclear matrix proteins (NMP) which are characterized by a defined expression in bladder tissue are provided, which can be used to generate antibodies that differentiate between normal and cancerous bladder tissue. These NMPs are useful markers in diagnosing and monitoring the stage of malignancy of a bladder cell and treating bladder cell proliferative disorders associated with the NMP. Also provided are substantially purified polypeptides and nucleotide sequences encoding the NMPs of the invention.
Claims10
An isolated or purified antibody that specifically binds to a nuclear matrix protein or an antigenic fragment thereof, wherein said nuclear matrix protein is present in cancerous bladder cells but absent in normal bladder cells, wherein the nuclear matrix protein is BLCA-4 having a molecular weight of about 37 kD and a pI of about 6.24.
Dependencies are inferred from the claim text.