Interleukin-1 receptor accessory proteins, nucleic acids and methods
AssigneeTularik Inc.
InventorZhaodan Cao
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Abstract
The invention provides methods and compositions relating to IL-1RAcP proteins that regulate cellular signal transduction and transcriptional activation, and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed IL-1RAcP encoding nucleic acids purified from human cells. The invention provides isolated IL-1RAcP hybridization probes and primers capable of specifically hybridizing with the disclosed IL-1RAcP genes, IL-1RAcP-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
Claims15
An isolated polypeptide comprising the amino acid sequence set forth as SEQ ID NO:2, or a fragment thereof comprising at least one of the amino acid sequences set forth as residues 321-361, residues 339-375, and residues 491-509 of SEQ ID NO:
- 2.
An isolated or recombinant nucleic acid encoding a polypeptide comprising the amino acid sequence set forth as SEQ ID NO:2, or a fragment thereof comprising at least one the amino acid sequences set forth as residues 321-361, residues 339-375, and residues 491-509 of SEQ ID NO:
- 2.
An isolated or recombinant nucleic acid comprising the polynucleotide sequence set forth as SEQ ID NO:1, or a fragment thereof comprising at least one of the polynucleotide sequences set for as nucleotides 965-1057 and nucleotides 1436-1530 of SEQ ID NO:1.
Dependencies are inferred from the claim text.