Method for prediction of PTH reactivity by polymorphism of PTHR gene
AssigneesYusuke Tsukamoto, Sumikin Bio-Science, Inc.
InventorsMasayuki Heishi, Osamu Ishida, Hiromitsu Tazawa, Yusuke Tsukamoto
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Abstract
A method for predicting reactivity to parathyroid hormone by determining the genotype with respect to polymorphism in the parathyroid hormone receptor gene. The results obtained by the analysis of genetic polymophism are useful for predicting the tendency for a hemodialyzed patient to develop severe secondary hyperparathyroidism, or for predicting the tendency for a human individual to develop severe primary hyperparathyroidism. Also, this method is useful for predicting the therapeutic effects by predicting reactivity to parathyroid hormone in a patient who is being treated for regressive osteoporosis by administration of parathyroid hormone.
Claims7
A method for predicting reactivity to parathyroid hormone in a human, comprising determining a genotype in the parathyroid hormone receptor gene with respect to Van91 I polymorphism, thereby predicting the reactivity to parathyroid hormone, wherein detection of the VV or Vv genotype in the parathyroid hormone receptor gene with respect to the Van91 I polymorphism indicates an increase in PTH reactivity relative to the vv genotype.
A primer set for use in analyzing the Van91 I polymorphism in the parathyroid hormone receptor gene, consisting of a primer having the sequence of SEQ ID NO:1 and a primer having the sequence of SEQ ID NO:2.
A method for predicting reactivity to parathyroid hormone in a patient who is being treated for regressive osteoporosis by administration of parathyroid horme, comprising determining a genotype in the parathyroid hormone receptor gene with respect to Van91 I polymorphism, thereby predicting the reactivity to parathyroid hormone.
Dependencies are inferred from the claim text.