Process for preparing natural product derivatives from plants in a single step
OwnerDaniel Gaudet, André Pichetteinventors
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Abstract
A process is disclosed, for preparing a derivative of a targeted natural product from plants. The targeted natural product is extracted from the desired part of the plant and the targeted natural product is transformed into the desired derivative(s). Both the extraction and transformation are carried out in a single step consisting of macerating the desired part of the plant into a composition comprising an organic solvent and a reactive agent. This process is particularly useful for preparing derivatives of betulin or lupeol from bark of birch.
Claims21
A process for preparing a derivative of a targeted natural product selected from the group consisting of betulin or lupeol, the process comprising a single step of:
- macerating a desired part of a plant known to contain the targeted natural product into a composition comprising:
- an organic solvent causing extraction of the targeted natural product from the desired part of the plant;
- and
- a reactive agent causing transformation of the extracted natural product into said derivative, said transformation being an oxidation or a rearrangement.
A process for preparing a derivative of betulin, the process comprising a single step of:
- macerating a bark of Betula papyrifera Marsh (white birch) in a composition comprising:
- an organic solvent causing extraction of betulin from said bark of white birch;
- and
- a reactive agent causing transformation of the betulin into said derivative, said transformation being an oxidation or a rearrangement;
- wherein the derivative of betulin is selected from the group of allobetulin, betulinic aldehyde, betulonic aldehyde, betulinic acid and betulonic acid.
Dependencies are inferred from the claim text.