Dosage forms exhibiting multi-phasic release kinetics and methods of manufacture thereof
AssigneesTherics, Inc., Massachusetts Institute of Technology
InventorsDonald Monkhouse, Jaedeok Yoo, Jill K. Sherwood, Michael J. Cima, Esteban Bornancini
Life of this patent
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Abstract
Dosage forms prepared by solid free form fabrication (SFF) provide release of medicament in multiple phases.
Claims15
A multiphasic dosage form comprising a three dimensional matrix including pharmaceutically acceptable particulates adhered together;
- at least one pharmaceutically active material incorporated into the matrix;
- and
- at least one complexing agent incorporated into the matrix and in contact with the pharmaceutically active material.
A multiphasic dosage form comprising a three dimensional matrix including pharmaceutically acceptable particulates adhered together;
- at least one pharmaceutically active material incorporated into the matrix;
- and at least one complexing agent incorporated into the matrix and in contact with the pharmaceutically active material wherein the complexing agent comprises a cylcodextrin or a derivative thereof.
A non-compressed drug delivery system comprising one or more active ingredients and a solid matrix harboring said one or more active ingredients, said matrix having a three dimensional architecture suitable for administration to a subject and which matrix comprises a bulk material and a binder, and which binder causes adhesion between the bulk materials and the binder, said bulk material being a biocompatible compound in a powder form and said binder comprising a pharmaceutically acceptable substance that together with said bulk material permits said matrix to maintain its three-dimensional architecture such that said pharmaceutical composition is released in a multiphasic pattern and said composition exhibits hardness and friability characteristics adequate to permit storage and handling of said composition.
Dependencies are inferred from the claim text.