Peptide-coated implants and methods for producing same
AssigneeMerck Patent Gesellschaft mit beschraenkter Haftung
InventorsJorg Meyer, Alfred Jonczyk, Berthold Nies, Horst Kessler, Dirk Finsinger, Martin Kantlehner
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Abstract
The invention describes the possibility of the biofunctionalization of biomaterials, in particular implants, by their made-to-measure coating with synthesized cell- or tissue-selective RGD peptides which in vitro stimulate the adhesion of mainly those cell species which in each case are intended to accomplish the tissue integration of the appropriate biomaterial.
Claims21
An implant suitable for a human or animal organ, comprising a carrier matrix and a peptide coating surrounding this matrix which contains different peptides for the targeted adhesion stimulation of human or animal body cells, wherein
- said peptides have a length of 3 to 20 amino acids and comprise sequences which recognize binding sites on integrin receptors responsible for adhesion on said human or animal cells,
- the carrier matrix has, bound to its surface reactive groups capable of entering into a stable covalent bond with functional reactive groups of said peptides or of anchor molecules for attaching said peptides to the carrier matrix surface,
- and said peptides are arranged of the surface of the implant such that their different structure-related, cell adhesion-stimulating activities correspond specifically to the natural different complementary integrin pattern of said human or animal cells in the particular region into which the implant is to be inserted, thereby forming a locally differentiated, selective, bioactive coating pattern on the implant surface.
Dependencies are inferred from the claim text.