Cosmetic or dermatological composition contacting at least one natural or recombinant spider silk or an analog
AssigneeL'oreal
InventorsMichel Philippe, Jean-Claude Garson, Jean-Pierre Arraudeau
Life of this patent
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Abstract
A cosmetic or dermatological composition containing, as an active substance, at least one natural or recombinant spider silk protein, or an analog of such a protein. The composition may be in the form of hair products, skincare products, make-up products or antisun products.
Claims92
A cosmetic or dermatological composition, comprising:
- (A) an effective amount of at least one natural or recombinant spider silk protein or an analog of a spider silk protein comprising an amino acid repeating unit of sequence (I):
- [(Xaa Gly Gly)w(Xaa Gly Ala)(Gly Xaa Gly)x(Ala Gly Ala)y(Gly)zAla Gly]p (SEQ ID NO:
- 11) (I)
- wherein
- Xaa is tyrosine or glutamine,
- w is an integer equal to 2 or 3,
- x is an integer from 1 to 3,
- y is an integer from 5 to 7,
- z is an integer equal to 1 or 2, and
- p is an integer such that the molecular weight of the protein is between 10 and 400 kDa;
- and
- (B) at least one cosmetic adjuvant selected from the group consisting of fillers, surfactants, UVA and/or UVB sunscreens, thixotropic agents, antioxidants, preserving agents, dyes, pigments, fragrances, thickeners, vitamins, hormones, moisturizers, wetting agents, anionic, nonionic or amphoteric polymers, and cosmetic or dermatological active substances.
A method of applying a spider silk protein or an analog of a spider silk protein to skin, nails, hair or mucous membranes, comprising applying a cosmetic or dermatological composition comprising an effective amount of at least one natural or recombinant spider silk protein or an analog of a spider silk protein comprising an amino acid repeating unit of sequence (I):
- [(Xaa Gly Gly)w(Xaa Gly Ala)(Gly Xaa Gly)x(Ala Gly Ala)y(Gly)zAla Gly]p (SEQ ID NO:
- 11) (I)
- wherein
- Xaa is tyrosine or glutamine,
- w is an integer equal to 2 or 3,
- x is an integer from 1 to 3,
- y is an integer from 5 to 7,
- z is an integer equal to 1 or 2, and
- p is an integer such that the molecular weight of the protein is between 10 and 400 kDa,
- to skin, nails, hair or mucous membranes.
An anhydrous cosmetic or dermatological composition, comprising:
- (A) at least one natural or recombinant spider silk protein or an analog of a spider silk protein comprising an amino acid repeating unit of sequence (I):
- [(Xaa Gly Gly)w(Xaa Gly Ala)(Gly Xaa Gly)x(Ala Gly Ala)y(Gly)zAla Gly]p (SEQ ID NO:
- 11) (I)
- wherein
- Xaa is tyrosine or glutamine,
- w is an integer equal to 2 or 3,
- x is an integer from 1 to 3,
- y is an integer from 5 to 7,
- z is an integer equal to 1 or 2, and
- p is an integer such that the molecular weight of the protein is between 10 and 400 kDa;
- and
- (B) 10 to 90% by weight, relative to the total weight of the composition, of a fatty phase, wherein the fatty phase contains at least one liquid, solid or semi-solid fatty substance.
A cosmetic or dermatological composition, comprising an effective amount of at least one natural or recombinant spider silk protein or an analog of a spider silk protein comprising an amino acid repeating unit of sequence (I):
- [(Xaa Gly Gly)w(Xaa Gly Ala)(Gly Xaa Gly)x(Ala Gly Ala)y(Gly)zAla Gly]p (SEQ ID NO:
- 11) (I)
- wherein
- Xaa is tyrosine or glutamine,
- w is an integer equal to 2 or 3,
- x is an integer from 1 to 3,
- y is an integer from 5 to 7,
- z is an integer equal to 1 or 2, and
- p is an integer such that the molecular weight of the protein is between 10 and 400 kDa,
- wherein the composition is in the form of an oily gel, a compacted powder, a cast powder, or a stick.
A composition, wherein the composition is in the form of a stable dispersion of water-in-oil or oil-in-water type, and comprises:
- (A) an effective amount of at least one natural or recombinant spider silk protein or an analog of a spider silk protein comprising an amino acid repeating unit of sequence (I):
- [(Xaa Gly Gly)w(Xaa Gly Ala)(Gly Xaa Gly)x(Ala Gly Ala)y(Gly)zAla Gly]p (SEQ ID NO:
- 11) (I)
- wherein
- Xaa is tyrosine or glutamine,
- w is an integer equal to 2 or 3,
- x is an integer from 1 to 3,
- y is an integer from 5 to 7,
- z is an integer equal to 1 or 2, and
- p is an integer such that the molecular weight of the protein is between 10 and 400 kDa;
- (B) a fatty phase in a proportion of from 0.1 to 50% by weight relative to the total weight of the composition, wherein the fatty phase contains a natural or recombinant spider silk protein, or an analog thereof, in a proportion of from 10-4 to 30% by weight relative to the total weight of the composition;
- (C) an aqueous phase in a proportion of from 50 to 98.9% by weight relative to the total weight of the composition;
- and
- (D) at least one emulsifier in a proportion of from 1 to 10% by weight relative to the total weight of the composition.
A composition, wherein the composition is in the form of a colorless or colored nail varnish, and comprises:
- (A) 10−4 to 30% by weight relative to the total weight of the composition of at least one natural or recombinant spider silk protein or an analog of a spider silk protein comprising an amino acid repeating unit of sequence (I):
- [(Xaa Gly Gly)w(Xaa Gly Ala)(Gly Xaa Gly)x(Ala Gly Ala)y(Gly)zAla Gly]p (SEQ ID NO:
- 11) (I)
- wherein
- Xaa is tyrosine or glutamine,
- w is an integer equal to 2 or 3,
- x is an integer from 1 to 3,
- y is an integer from 5 to 7,
- z is an integer equal to 1 or 2, and
- p is an integer such that the molecular weight of the protein is between 10 and 400 kDa;
- (B) a solvent mixture suitable for a nail varnish;
- and
- (C) a film-forming substance.
Dependencies are inferred from the claim text.