Methods and compositions for the delivery of pharmaceutical agents and/or the prevention of adhesions
AssigneeAlliance Pharmaceutical Corp.
InventorsStephen G. Flore, Luis A. Dellamary, Lorraine E. Reeve, Jeffry G. Weers
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Abstract
The present invention provides a composition comprising one or more constitutive polymers and modifier polymers and/or hydrophilic co-surfactants useful for reducing adhesions or delivering bioactive agents. Methods for preventing and/or reducing post-surgical adhesions or delivering bioactive agents are provided.
Claims28
A pharmaceutical aqueous-gel composition, said composition comprising a constitutive polymer selected from the group consisting of polyoxyalkylene block copolymers and polyoxyalkylene polyethers and combinations thereof, further including a modifier polymer selected from the group consisting of cellulose ethers, sodium carboxymethylcellulose and polyacrylates and further including a co-surfactant comprising at least one fatty acid soap.
A pharmaceutical aqueous-gel composition, said composition comprising constitutive polymers of the formula:
- (R)2N—(CH2)2—N(R)2
- wherein R is H(OC2H4)b(OC3H6)a— and a and b are integers such that the hydrophobic base represented by (C3H6O)a has a sum average molecular weight of at least about 2000, said composition further including a modifier polymer selected from the group comprising cellulose ethers, sodium carboxymethylcellulose and polyacrylates and further including a co-surfactant comprising at least one fatty acid soap.
Dependencies are inferred from the claim text.