Stable extract of Hypericum perforatum L.,process for preparing the same and pharmaceutical compositions
AssigneeUr. Willmar Schwabe GmbH & Co,
InventorsClemens Erdelmeier, Eckhart Grethlein, Friedrich Lang, Rainer Oschmann, Karl-Heinz Stumpf
Life of this patent
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Abstract
Disclosed is an improved extract of Hypericum perforatum L. (St. John's wort) containing Hyperforin, in which the Hyperforin is stabilized against decomposition or degradation by means of a stabilizer.
Claims33
A stable extract of Hypericum perforatum L. (St. John's wort) containing Hyperforin, wherein the extract comprises an amount of a stabilizer selected from the group consisting of organic thiol compounds, ascorbic acid, ascorbic acid derivatives, and mixtures thereof effective to stabilize the Hyperforin against decomposition or degradation.
In a process for the preparation of a stable Hyperforin-containing extract wherein Hypericum perforatum L. plant material is extracted with pharmaceutical inorganic or organic solvents or mixtures thereof, with the proviso that the solvents are not oily extraction agents, the improvement comprising adding a stabilizer selected from organic thiol compounds, ascorbic acid and derivatives thereof either during or after the preparation of the extract, in an amount sufficient to stabilize the Hyperforin.
A stable composition comprising
- (a) hyperforin extracted from Hypericum perforatum L. using water and methanol or ethanol;
- and
- (b) an amount of a stabilizer selected from the group consisting of organic thiol compounds, ascorbic acid, ascorbic acid derivatives, and mixtures thereof effective to stabilize the Hyperforin against decomposition or degradation.
A plant extract comprising
- (a) hyperforin;
- and
- (b) an amount of a stabilizer selected from the group consisting of organic thiol compounds, ascorbic acid, ascorbic acid derivatives, and mixtures thereof effective to stabilize the hyperforin against decomposition or degradation, the hyperforin being stable in the composition for at least 12 months.
Dependencies are inferred from the claim text.