Microtubule-associated protein
AssigneeIncyte Genomics, Inc.
InventorsJennifer L. Hillman, Surya K. Goli
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Abstract
The present invention provides a human microtubule-associated protein (hLC3) and the polynucleotides which identify and encode hLC3. The invention also provides genetically engineered expression vectors, host cells, and a method for producing hLC3. The invention also provides hLC3 as well as agonists, antibodies, and antagonists of hLC3, and the use thereof for the prevention and treatment of diseases associated with the expression of hLC3. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding hLC3 for the treatment of diseases associated with the expression of hLC3. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding hLC3.
Claims8
A purified polypeptide comprising an amino acid sequence as shown in SEQ ID NO:1.
A purified polypeptide comprising an amino acid sequence having at least 90% sequence identity to an amino acid sequence shown in SEQ ID NO:1, and wherein said polypeptide binds to microtubules.
A biologically-active fragment of a polypeptide, wherein said polypeptide comprises an amino acid sequence as shown in SEQ ID NO:1, and wherein said biologically-active fragment binds to microtubules.
An immunogenic fragment of a polypeptide, wherein said polypeptide consists of an amino acid sequence as shown in SEQ ID NO:1, and wherein said immunogenic fragment generates an antibody that specifically binds to said polypeptide.
Dependencies are inferred from the claim text.