Methods of using an AL-1 neurotrophic factor immunoadhesin
AssigneeGenentech, Inc.
InventorsIngrid W. Caras, John W. Winslow
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Abstract
The present invention provides nucleic acids encoding AL-1 protein, as well as AL-1 protein produced by recombinant DNA methods. Such AL-1 protein is useful in preparing antibodies and in diagnosing and treating various neuronal disorders.
Claims5
A method of activating the autophosphorylation of REK7 comprising administering intracerebrally an AL-1 immunoadhesin comprising the mature AL-1 polypeptide as set forth as amino acid residues 21-228 of SEQ ID NO:4 in an amount effective to activate REK7.
A method of activating the autophosphorylation of REK7 comprising administering intracerebrally an AL-1 immunoadhesin comprising an AL-1 polypeptide as set forth as amino acid residues 21-228 of SEQ ID NO:4, wherein said AL-1 polypeptide has a deletion of 1 to 30 contiguous amino acid residues from the amino acid residues set forth as residues 21-228 of SEQ ID NO:4, in an amount effective to activate REK7.
Dependencies are inferred from the claim text.