Diagnostic method for detection of periodontitis or peri-implantitis
AssigneesThe Research Foundation of State University of NY, Oy Medix Biochemica AB
InventorsLorne M. Golub, Timo Sorsa, Olli Teronen, Sari Hannele Tikanoja
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Abstract
The invention relates to methods and test kits for diagnosis of periodontal disease activity in mammals, especially in human. The methods of the invention provide for rapid chair-side diagnosis of periodontitis, peri-implantitis and HIV (+)-infection/AIDS-disease related periodontal diseases. Especially, the methods of the invention provide for rapid chair-side diagnosis of the loss of bone density associated with periodontal diseases.
Claims18
A test kit for monitoring the course and treatment of periodontal diseases or peri-implantitis comprising at least one detectable label;
- at least one molecule which specifically recognizes mammalian matrix metalloproteinase-13 (MMP-13) in gingival crevicular fluid, peri-implant sucular fluid, saliva or mouthrinse samples;
- and either (i) a stimulant of saliva excretion, (ii) a solid absorbent site-specific sampling device, or (iii) a mouthrinse vial;
- wherein an increased level of MMP-13 indicates periodontal disease or peri-implantitis.
Dependencies are inferred from the claim text.