Column for chromatography
AssigneePharmacia Biotech AB
InventorConny Pettersson
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Abstract
Disclosed is a chromatography column having adapters that include an end-plate and a perforated plate such as to form a gap between the end-plate and the perforated plate. The column is particularly suited for large-scale chromatography in which matrices of small particle sizes are used.
Claims13
A liquid-chromatography column constructed from a column tube that includes a chromatographic matrix, a flow inlet and a flow outlet and an adaptor placed at the inlet and outlet respectively, characterized in that the respective adaptors include an end-plate and a perforated plate configured to define a gap between the end-plate and the perforated plate, wherein said gap is created by projections on the end-late or the perforated plate and wherein the projections create a continuous vertical layer which allows continuous radial fluid flow across the end area of the matrix.
A liquid-chromatography column constructed from a column tube that includes a chromatographic matrix, a flow inlet having a centrally located inlet opening and a flow outlet having a centrally located outlet opening, and an adaptor placed at the inlet and outlet respectively, characterized in that the respective adaptors include a planar end-plate and a planar perforated plate containing a plurality of openings, configured to define a single contiguous gap of greater than 0.2 mm between the end-plate and the perforated plate, wherein said gap is created by a plurality of discrete projections on the end-late or the perforated plate, wherein said projections on one of said plates contact the other of said plates to form said gap, and wherein the projections create a continuous vertical layer which allows continuous radial fluid flow across the end area of the matrix.
Dependencies are inferred from the claim text.