Asymmetric synthesis catalyzed by transition metal complexes with rigid chiral ligands
AssigneeThe Penn State Research Foundation
InventorXumu Zhang
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Abstract
This invention is to develop novel transition metal catalysts for the practical synthesis of important chiral molecules. The invention emphasizes asymmetric catalysis based on chiral bidentate phosphine ligands with cyclic ring structures which could be used to restrict conformational flexibility of the ligands and thus the efficiency of chiral transfer can be enhanced through the ligand rigidity
Claims8
A chiral bisphosphine ligand for performing asymmetric synthesis, wherein said ligand comprises an enantiomer of a (2, 2′)-bis(diarylphosphino)-(1,1′)-dicyclo compound having saturated carbons at the 2, 2′, 1, and 1′ positions, and wherein each aryl is 3, 5-alkyl substituted or 4-alkyl substituted.
Dependencies are inferred from the claim text.