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US 6,277,628 B1Granted
Linear microarrays
AssigneeIncyte Genomics, Inc.
InventorsTimothy W. Johann, Sang Chul Park
Life of this patent
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Abstract
The present invention provides a method and a composition for detecting the levels of a plurality of biomolecular probes in a sample. In particular, the invention relates to a hybridization composition for detecting the presence or levels of different polynucleotide sequences in a sample.
Claims41
A device for detecting a plurality of biomolecular probes in a sample, said device comprising a vessel comprising:
- (a) a casing having an inner surface and input and output openings,
- (b) a nonporous substrate having an outer surface and contained within said casing,
- (c) a liquid sample comprising biomolecular probes and contained within said casing,
- wherein the substrate outer surface contains a plurality of regions arranged in a defined manner and each of said regions has a different one of a plurality of immobilized specific binding targets which specifically bind a corresponding one of the plurality of the biomolecular probes, and said substrate outer surface is in close proximity with the inner surface of said casina so as to minimize the ratio of the liquid sample volume contained within said casing to the substrate outer surface area, yet permit flow of the liquid sample from the input opening, between the substrate outer surface and the casing inner surface, and to the output opening.
1 more element
Dependencies are inferred from the claim text.