Support for high performance affinity chromatography and other uses

A multilayered material comprising:

• a particulate substrate;
• a metal film essentially completely coating said substrate, applied to said substrate by electroless deposition;
• and
• an organic layer attached to said metal film, comprising;
• X1 Q2C(CQ12)m(Z1)o(CQ22)nS—
• wherein,
• X1 is a member selected from the group consisting of halogen, drugs, chelating agents, crown ethers, cyclodextrins, antibodies, antigens, carbohydrates, nucleic acids, peptides, enzymes, receptors and combinations thereof;
• Q, Q1 and Q2 are independently members selected from the group consisting of H and halogen;
• Z1 is a member selected from the group consisting of —CQ2—, —CQ12—, —CQ22—, —O—, —S—, —NR—, —C(O)NR1 and R1NC(O)—,
• in which;
• R1 is a member selected from the group consisting of H, alkyl, substituted alkyl, aryl, substituted aryl, heteroaryl and heterocyclic groups;
• m is a number from 0 to 40;
• n is a number from 0 to 40;
• and
• o is a number from 0 to 5.

A multilayered material comprising:

• a particulate substrate;
• a metal film essentially completely coating said substrate, applied to said substrate by electroless deposition;
• and
• an organic layer attached to said metal film, comprising;
• R2OCH2CH2(OCH2CH2)u(CH2)vS—
• wherein,
• R2 is a member selected from the group consisting of H, alkyl, acyl and recognition moieties;
• u is a number from 1 to 50;
• and
• v is a number from 0 to 20.