Reaction plenum with magnetic separation and/or ultrasonic agitation
AssigneeSolid Phase Sciences Corporation
InventorIrving Sucholeiki
Life of this patent
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Abstract
The inventive apparatus is comprised of a means for producing cavitation in a complex reaction mixture to enhance the yield of the selected reaction product, a means for controlling the temperature of the complex reaction mixture, especially during cavitation, and a means for affecting magnetic separation of paramagnetic beads to which the selected reaction product is attached from the complex reaction mixture. In one embodiment, the compound(s) or molecule(s) is synthesized in situ, and isolated using the inventive apparatus. The apparatus finds use in the fields of solid phase organic synthesis, and for isolation and purification of a selected compound(s) or molecule (s), especially where automation is desired.
Claims32
Apparatus for performing an organic chemical reaction comprising:
- a liquid bath;
- at least one reaction vessel arranged to be positioned in said liquid bath;
- at least one paramagnetic bead in said at least one reaction vessel;
- transporting means for positioning said at least one reaction vessel in said liquid bath;
- ultrasonic means external to said reaction vessel for providing an ultrasonic field in said reaction vessel;
- computer means for controlling said ultrasonic field;
- magnetic field means in said liquid bath for providing a magnetic field;
- and
- means for selectively exposing said reaction vessel to said ultrasonic field and to said magnetic field.
Apparatus for performing an organic chemical reaction comprising:
- a liquid bath;
- at least one reaction vessel arranged to be positioned in said liquid bath;
- at least one paramagnetic bead in said at least one reaction vessel;
- dispensing means for dispensing a solvent into said at least one reaction vessel;
- transporting means for positioning said at least one reaction vessel in said liquid bath;
- ultrasonic means external to said reaction vessel for providing an ultrasonic field in said reaction vessel;
- magnetic field means in said liquid bath for providing a magnetic field;
- and
- means for selectively exposing said reaction vessel to said ultrasonic field and to said magnetic field.
Apparatus for performing an organic chemical reaction comprising:
- a liquid bath;
- at least one reaction vessel arranged to be positioned in said liquid bath;
- at least one paramagnetic bead in said at least one reaction vessel;
- transporting means for positioning said at least one reaction vessel in said liquid bath;
- said transporting means includes supply means for supplying an inert atmosphere to said reaction vessel;
- ultrasonic means external to said reaction vessel for providing an ultrasonic field in said reaction vessel;
- magnetic field means in said liquid bath for providing a magnetic field;
- and
- means for selectively exposing said reaction vessel to said ultrasonic field and to said magnetic field.
Apparatus for performing an organic chemical reaction comprising:
- a liquid bath;
- temperature control means for regulating the temperature of said liquid;
- at least one reaction vessel arranged to be positioned in said liquid bath;
- at least one paramagnetic bead in said at least one reaction vessel;
- transporting means for positioning said at least one reaction vessel in said liquid bath;
- ultrasonic means external to said reaction vessel for providing an ultrasonic field in said reaction vessel;
- magnetic field means in said liquid bath for providing a magnetic field;
- and
- means for selectively exposing said reaction vessel to said ultrasonic field and to said magnetic field.
Apparatus for performing an organic chemical reaction in a plurality of reaction vessels positioned in a liquid bath, at least one of said reaction vessels provided with at least one non-paramagnetic bead, said apparatus comprising:
- a liquid bath;
- a plurality of reaction vessels positioned within said liquid bath;
- a reverse filtration system operably associated with said reaction vessels, said reverse filtration system separating solids from liquids within each of said plurality of said reaction vessels;
- ultrasonic means located in said liquid bath external to said reaction vessels for substantially simultaneously providing an ultrasonic field in all of said reaction vessels;
- and
- means for controlling the ultrasonic means by actuating and deactuating the ultrasonic means and for controlling the amplitude and duration of the ultrasonic field of said ultrasonic means to produce a field across said plurality of reaction vessels.
Apparatus for performing an organic chemical reaction in a plurality of reaction vessels positioned in a liquid bath, said reaction vessels provided with a starting material dissolved in an organic solvent, said apparatus comprising:
- a liquid bath;
- a plurality of reaction vessels positioned within said liquid bath;
- ultrasonic means located in said liquid bath external to said reaction vessels for substantially simultaneously providing a substantially uniform ultrasonic field in all of said plurality of said reaction vessels;
- said ultrasonic means having an ultrasonic emitting surface area underlying all of said plurality of said reaction vessels;
- and
- means for controlling the ultrasonic means by actuating and deactuating the ultrasonic means and for controlling the amplitude and duration of the ultrasonic field of said ultrasonic means to produce a substantially uniform field across said plurality of reaction vessels.
Apparatus for performing an organic chemical reaction comprising:
- a liquid bath;
- a plurality of reaction vessels arranged to be positioned in said liquid bath;
- at least one paramagnetic bead in at least one of said reaction vessels;
- transporting means operably connected to said reaction vessels for positioning said reaction vessels in said liquid bath;
- ultrasonic means external to said reaction vessels for providing an ultrasonic field in said reaction vessels;
- magnetic field means in said liquid bath for providing a magnetic field;
- and
- means for selectively exposing said reaction vessels to said ultrasonic field and to said magnetic field.
Dependencies are inferred from the claim text.