Thin polymer film drug reservoirs
AssigneeAlza Corporation
InventorsSubramanian S. Venkatraman, Eli J. Goldman, Lothar W. Kleiner, Stephanus Pudjijanto
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Abstract
The present invention relates to hydratable drug reservoir films for electrotransport drug delivery devices and to electrotransport drug delivery systems containing the hydratable drug reservoirs and to methods for manufacturing and using such systems. The hydratable reservoir films according to this invention are easily manufacturable and rapidly imbibe water and/or drug solution with good water retention and stability.
Claims28
A thin film drug reservoir for an electrotransport drug delivery device comprising a hydratable, hydrophilic polymer, said film capable of forming a hydrogel when placed in contact with a hydrating liquid, said film, when hydrated at about 400%, having a shear modulus G′ of about 1-100 kPa and wherein said film when substantially non-hydrated, is capable of absorbing at least about four times its weight in hydrating liquid within about 30 minutes.
A multilaminate dry state electrode assembly for an electrolytic transdermal agent delivery device, said electrode assembly comprising:
- a reservoir layer including a substantially non-hydrated hydratable matrix containing an agent to be delivered, the reservoir layer being adapted to be placed in agent transmitting relation with a body surface, and
- an electrode layer in electrical contact with both the reservoir layer and a power source,
- wherein said hydratable matrix comprises a hydratable, hydrophilic polymer film, said film capable of forming a hydrogel when placed in contact with a hydrating liquid, said film, when hydrated to about 400%, having a hydrated shear modulus G′ of about 1-100 kPa and wherein said film, when substantially non-hydrated, is capable of absorbing at least about four times its weight in hydrating liquid within about 30 minutes.
Dependencies are inferred from the claim text.