Methods of enhanced light transmission through turbid biological media

A method of reducing light scattering within biological tissue, said method comprising:

• delivering a first biocompatible fluid within said biological tissue;
• soaking said biological tissue with said first biocompatible fluid;
• replacing intercellular fluid of said biological tissue with said first biocompatible fluid;
• and
• reducing light scattering within said biological tissue by causing the ratio of refractive index of cellular components within the tissue to the refractive index of intercellular fluids to be closer to one than a native state.

A method of reducing light attenuation within biological media, said method comprising:

• providing a replacement fluid having a lower absorption coefficient than water at one or more water absorption peaks;
• and
• delivering an effective amount of said replacement fluid within said biological media to:
• soak said biological media with said replacement fluid;
• replace intercellular fluid within said biological media with said replacement fluid;
• and
• reduce light absorption within said biological media.