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US 6,274,758 B1Granted
Asymmetric hydrogenation of vinyl sulfones
AssigneeDarwin Discovery, Ltd.
InventorsJane Marie Paul, Christopher Palmer
Life of this patent
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Abstract
A process for the preparation of an enantioenriched sulfone of formula (1), which comprises asymmetric hydrogenation of vinyl sulfone of formula (2) wherein R1 and R2 are each independently a hydrocarbon group of less than 20 carbons atoms, optionally substituted at any position, or either of R1 and R3 is H, and X is a coordinating group, in the presence of a stereoselective chiral catalyst.
Claims14
A process for the preparation of an enantioenriched sulfone of formula (1), comprising asymmetric hydrogenation of a vinyl sulfone of formula (2)
- in the presence of a stereoselective chiral catalyst, wherein R1, R2, and R3 are each independently a hydrocarbon group of less than 20 carbon atoms, optionally substituted at any position, or either of R1 and R3 is H, and X is a coordinating group selected from the group consisting of CO2H or a salt form thereof, CO2R, CONHOH, CONH2, CONHR, and CONR2 and each R is independently a hydrocarbon substituent of up to 20 carbon atoms.
Dependencies are inferred from the claim text.