Back to results
US 6,274,757 B1Granted
Neuromuscular relaxants
AssigneeNewlaxant LLC
InventorsLaszlo Gyermek, Chingmuh Lee, Young-Moon Cho
Life of this patent
Estimating the term…
Abstract
Alkoxy and/or acyloxy disubstituted and polysubstituted aralkyl and aralkenyl bis-quaternary ammonium derivatives of cyclic alkanol diesters have neuromuscular relaxant properties.
Claims4
A process for preparing a compound of the formula
- where R1 is di- or polysubstituted aralkyl or aralkenyl;
- R2 is alkyl or alkenyl;
- provided that at least one substituent on each aralkyl or aralkenyl group is alkoxy or acyloxy;
- A is normal or substituted alkanedicarbonyl, alkenedicarbonyl, alkynedicarbonyl, cycloalkanedicarbonyl, cycloalkenedicarbonyl, bicycloalkanedicarbonyl, bicycloalkenedicarbonyl, polycycloalkanedicarbonyl, or aromatic dicarbonyl;
- n is 0, 1, or 2;
- m is 0, 1, or 2;
- p is 0, 1, or 2;
- R3 is H, CH3, or lower alkyl;
- R4 is H, CH3, or lower alkyl;
- R3 and R4 together can also be —(CH2)g—, —CH═CH—, —(CH2)h—O—(CH2)k—, or —(CH2)h—S—(CH2)k—, where g is 2, 3, 4, or 5, h is 1 or 2, and k is 1 or 2;
- and X is a pharmaceutically acceptable anion;
- which comprises reacting a compound of the formula
- with a compound of the formula
- Cl—A—Cl
- to produce a first reaction product of the formula
- and reacting said first reaction product with a compound of the formula
- R1X
- to produce a second reaction product of the formula
15 more elements
A process for preparing a compound of the formula
- where R1 is di- or polysubstituted aralkyl or aralkenyl;
- R2 is alkyl or alkenyl;
- provided that at least one substituent on each aralkyl or aralkenyl group is alkoxy or acyloxy;
- A is normal or substituted alkanedicarbonyl, alkenedicarbonyl, alkynedicarbonyl, cycloalkanedicarbonyl, cycloalkenedicarbonyl, bicycloalkanedicarbonyl, bicycloalkenedicarbonyl, polycycloalkanedicarbonyl, or aromatic dicarbonyl;
- n is 0, 1, or 2;
- m is 0, 1, or 2;
- R3 is H, CH3, or lower alkyl;
- R4 is H, CH3, or lower alkyl;
- R3 and R4 together can also be —(CH2)g—, —CH═CH—, —(CH2)h—O—(CH2)k—, or —(CH2)h—S—(CH2)k—, where g is 2, 3, 4, or 5, h is 1 or 2, and k is 1 or 2;
- and X is a pharmaceutically acceptable anion;
- which comprises reacting a compound of the formula
- with a compound of the formula
- R1X
- to produce a first reaction product of the formula
- and reacting said first reaction product with a compound of the formula
- Cl—A—Cl
- to produce a second reaction product of the formula
14 more elements
A process for preparing a compound of the formula
- where R1 is di- or polysubstituted aralkyl or aralkenyl;
- provided that at least one substituent on each aralkyl or aralkenyl group is alkoxy or acyloxy;
- A is normal or substituted alkanedicarbonyl, alkenedicarbonyl, alkynedicarbonyl, cycloalkanedicarbonyl, cycloalkenedicarbonyl, bicycloalkanedicarbonyl, bicycloalkenedicarbonyl, polycycloalkanedicarbonyl, or aromatic dicarbonyl;
- n is 0, 1, or 2;
- m is 0, 1, or 2;
- p is 0, 1, or 2;
- R3 is H, CH3, or lower alkyl;
- R4 is H, CH3, or lower alkyl;
- R3 and R4 together can also be —(CH2)g—, —CH═CH—,—(CH2)h—O—(CH2)k—, or —(CH2)h—S—(CH2)k—, where g is 2, 3, 4, or 5, h is 1 or 2, and k is 1 or 2;
- and X is a pharmaceutically acceptable anion;
- which comprises reacting a compound of the formula
- with a compound of the formula
- Cl—A—Cl
- to produce a first reaction product of the formula
- and reacting said first reaction product with a compound of the formula
- R1X
- to produce a second reaction product of the formula
14 more elements
A process for preparation of a compound of the formula
- where R1 and R1′ are di- or polysubstituted aralkyl or aralkenyl;
- R2 and R2′ are alkyl or alkenyl;
- provided that at least one substituent on each aralkyl or aralkenyl group is alkoxy or acyloxy;
- A is normal or substituted alkanedicarbonyl, alkenedicarbonyl, alkynedicarbonyl, cycloalkanedicarbonyl, cycloalkenedicarbonyl, bicycloalkanedicarbonyl, bicycloalkenedicarbonyl, polycycloalkanedicarbonyl, or aromatic dicarbonyl;
- n is 0, 1, or 2;
- m is 0, 1, or 2;
- p is 0, 1, or 2;
- R3 and R3′ are H, CH3, or lower alkyl;
- R4 and R4′ are H, CH3, or lower alkyl;
- R3 and R4 together can also be —(CH2)g—, —CH═CH—,—(CH2)h—O—(CH2)k—, or —(CH2)h—S—(CH2)k—, where g is 2, 3, 4, or 5, h is 1 or 2, and k is 1 or 2 and R3′ and R4′ together can also be —(CH2)g—, —CH═CH—, —(CH2)h—O—(CH2)k—, or —(CH2)h—S—(CH2)k—, where g is 2, 3, 4, or 5, h is 1 or 2, and k is 1 or 2;
- where R1 and R1′, R2 and R2′, R3 and R3′, and R4 and R4′ can be the same or different;
- and X is a pharmaceutically acceptable anion;
- which comprises reacting a compound of the formula
- with about one equivalent of a compound of the formula
- R1X
- and then reacting the resulting first reaction product with about one equivalent of a compound of the formula
- R1′X
- to produce a second reaction product of the formula
15 more elements
Dependencies are inferred from the claim text.