Polyunsaturated fatty acid derivatives and their use
AssigneeArdenia Investments, Ltd.
InventorOleg Strelchenok
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Abstract
Novel amides are disclosed, in particular amides of the all-trans-retinoic acid or 13-cis-retinoic acid and arachidonic acid and docosahexaenoic acid and eicosapentaenoic acid or linoleic acid with 2-aminoethanol, alpha-L-serine, alpha-L-threonine, alpha-L-tyrosine containing phosphate groups. Further, the present invention discloses the synthesis and use of these compounds, in particular their pharmaceutical application.
Claims13
Compounds having the following formula
- R—CONH—X—OPO(OH)2
- wherein R is independently selected from
- and
- CH3(CH2)4(CH══CH—CH2)4CH2CH2—
- and
- CH3(CH2CH══CH)6CH2CH2—
- and
- CH3(CH2CH══CH)5(CH2)3—
- and
- CH3(CH2CH══CH)3(CH2)7—
- and where X is independently selected from
- —CH2—CH2—
- and
- —CH(CO2H)—CH2—
- and
- —CH(CO2H)—CH(CH3)—
- and
- —CH(CO2H)—CH2—C6H5—,
- said compound being other than the compound:
A compound selected from the group consisting of:
- N-(all-trans-retinoyl)-o-phospho-2-aminoethanol,
- N-(13-cis-retinoyl)-o-phospho-2-aminoethanol,
- N-(all-trans-retinoyl)-o-phospho-L-serine,
- N-(13-cis-retinoyl)-o-phospho-L-serine,
- N-(all-trans-retinoyl)-o-phospho-L-threonine,
- N-(13-cis-retinoyl)-o-phospho-L-threonine,
- N-(all-trans-retinoyl)-o-phospho-L-tyrosine, and
- N-(13-cis-retinoyl)-o-phospho-L-tyrosine.
A compound selected from the group consisting of:
- N-linolenoyl-o-phospho-2-aminoethanol,
- N-linolenoyl-o-phospho-L-serine,
- N-linolenoyl-o-phospho-L-threonine, and
- N-linolenoyl-o-phospho-L-tyrosine.
A compound selected from the group consisting of:
- N-docosahexaenoyl-o-phospho-2-aminoethanol,
- N-docosahexaenoyl-o-phospho-L-serine,
- N-docosahexaenoyl-o-phospho-L-threonine, and
- N-docosahexaenoyl-o-phospho-L-tyrosine.
A compound selected from the group consisting of:
- N-eicosapentaenoyl-o-phospho-2-aminoethanol,
- N-eicosapentaenoyl-o-phospho-L-serine,
- N-eicosapentaenoyl-o-phospho-L-threonine, and
- N-eicosapentaenoyl-o-phospho-L-tyrosine.
A compound selected from the group consisting of:
- N-arachidonoyl-o-phospho-L-serine,
- N-arachidonoyl-o-phospho-L-threonine, and
- N-arachidonoyl-o-phospho-L-tyrosine.
Dependencies are inferred from the claim text.