Process for allylic oxidation using metal hypochlorite and alkyl hydroperoxide
OwnerPadma Marwah, Henry A. Lardy +1inventors
InventorsPadma Marwah, Henry A. Lardy, Ashok Kumar Marwah
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Abstract
The present invention is directed to a process for effecting the allylic oxidation of an allylic compound having at least two allylic hydrogen atoms on the same carbon atom into corresponding α,β-unsaturated carbonyl compound, using a combination of a metal hypochlorite and an alkyl hydroperoxide in a mixture of suitable conventional organic solvent(s) and/or water at a temperature of between about −5° C. to +25° C.
Claims20
A process for effecting the allylic oxidation of an allylic compound having at least two allylic hydrogen atoms on the same carbon atom into corresponding α,β-unsaturated carbonyl compound, consisting of oxidizing said allylic compound in a mixture consisting of allylic compound to be oxidized, and an alkyl hydroperoxide in an inert organic solvent system and/or water, by addition of a metal hypochlorite at a temperature of about −5° C. to +25° C.
A process for effecting the allylic oxidation of an allylic compound having at least two allylic hydrogen atoms on the same carbon atom into corresponding α,β-unsaturated carbonyl compound, consisting of oxidizing said allylic compound in a mixture consisting of allylic compound to be oxidized, and tert-butyl hydroperoxide in an inert organic solvent system and/or water, by slow and steady addition of an aqueous solution of sodium hypochlorite with continuous stirring during the reaction period while maintaining the temperature of the reaction mixture at about 0° C. to 10° C.
Dependencies are inferred from the claim text.