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US 6,274,740 B1Granted
Process for the production of amorphous [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethy)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1)
AssigneeWarner-Lambert Company
InventorsMin Lin, Dieter Schweiss
Life of this patent
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Abstract
A novel process for the preparation of amorphous atorvastatin is described where crystalline Form I atorvastatin is dissolved in a non-hydroxylic solvent and after removal of the solvent affords amorphous atorvastatin.
Claims3
A process for the preparation of amorphous atorvastatin or hydrates thereof which comprises:
- (a) dissolving crystalline Form I atorvastatin having the formula
- in a non-hydroxylic solvent at a concentration of about 25% to about 40%;
- and
- (b) removing the solvent by drying to afford said amorphous atorvastatin or hydrates thereof.
1 more element
A process for the preparation of anhydrous amorphous atorvastatin which comprises:
- (a) dissolving crystalline Form I atorvastatin having the formula
- in a non-hydroxylic solvent at a concentration of about 25% to about 40%;
- and
- (b) removing the solvent by drying to afford said anhydrous amorphous atorvastatin.
1 more element
A process for the preparation of hydrated amorphous atorvastatin which comprises:
- (a) dissolving crystalline Form I atorvastatin having the formula
- in a non-hydroxylic solvent at a concentration of about 25% to about 40%;
- and
- (b) removing the solvent by drying to afford said hydrated amorphous atorvastatin.
1 more element
Dependencies are inferred from the claim text.