Endothelin receptor antagonists

A compound of Formula (I):

• wherein:
• R1 is —X(CH2)nAr′, dihydrobenzofuranyl, benzodioxanyl,
• cyclohexyl or C1-4alkyl, wherein Ar′ is a moiety of formula (a) or (b);
• wherein A is C═O, or (C(R6)2)m;
• and
• B is —CH2— or —O—;
• R2 is a moiety of fornula (a) or (b);
• P1 is —X(CH2)nRg;
• P2 is hydrogen or C1-4alkyl,
• R6 is independently hydrogen or C1-10alkyl;
• R7 is independently hydrogen, C1-4alkyl, C2-10alkenyl or C2-8alkynyl, all of which may be unsubstituted or substituted by one or morc OH, N(R6)2, CO2R12, Br, Cl, F, I, or XC1-5alkyl;
• or R7 is (CH2)nAr;
• R8 is hydrogen, R11, CO2R7, CO2C(R11)2O(CO)XR7, PO3(R7)2, SO2NR7R11, N7SO2R11,CONR7SO2R11, SO3R7, SO2RR7, P(O)(OR7)R7, CN, —CO2(CH2)mC(O)N(R6)2, C(R11)2N(R7)2, C(O)N(R6)2, tetrazole or OR6;
• R9 is a bond, C1-10alkylene, C2-10alkenylene, C1-10alkylidene, C2-10aldkynylene, all of which may be linear or branched, or R9 is phenylene, all of which may be unsubstituted or substituted by one or more OH, N(R6)2, COOH or halogen;
• R10 is hydrogen;
• R11 is hydrogen, Ar, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, all of whiich may be unsubstituted or substituted by one or more OH, CH2OH, N(R6)2′Br, Cl, I, or F;
• R12 is hydrogen, C1-6alkyl, C2-6alkenyl or C2-7alkynyl;
• R13 is divalent Ar, C1-10alkylene, C1-10alkylidene, C2-10alkenylene, C2-10alkynylene, all of which may be unsubstltuted or substituted by one or two OH, CH2OH, N(R6)2 Br, Cl, I, or F;
• X is (CH2)n or O;
• Y is CH3 or X(CH2)nAr;
• Ar is naplthyl, indolyl, pyridyl, thienyl, oxazolidinyl, oxazolyl, thiazolyl, isothiazolyl, pyrazolyl, triazolyl, tetrazolyl, imidazolyll imidazolidinyl, thiazolidinyl, isoxazolyl, oxadiazolyl, thiadiazolyl, morpholinyl, piperidinyl, piperazinyl, prolyl, or pyrimidyl;
• all of which may be unsubstituted or substituted by one or two OH, C1-5alkoxy, I, Br, F, Cl, —OC1-4alkylphenyl, R13CO2R7, C1-4alkyl, —N(R)6)2, —NH(CO)CH3, —X(CH2)nRg, —X—R9—Y, pyridyl, phenyl or S(O)qCl5alkyl, provided that when R13, R8 pr Y are Ar, the Ar is not substituted by another Ar which is further substituted by an yet another Ar;
• Z1, Z2 and Z3 are independently hydrogen, OH, C1-8alkoxy, S(O)qC1-8alkyl, N(R6)2, Br, F, I, Cl, NHCOR6, —X—R9—Y, —X(CH2)nR8;
• or Z1 and Z2 together may be —O—A—O— on contiguous carbons;
• q is zero, onc or two;
• n is an integer from 0 to six;
• m is 1, 2 or 3;
• or a pharmaceutically acceptable salt thereof;
• provided that
• when Z1, Z2, or Z3 is X(CH2)nR8, n is not 0 when X is oxygcn and R8 is OR6 or CO2H;
• and
• P1 is not CO2H, C(R6)2COOH or tetrazole wien P2 is hydrogen and Ar is pyridyl.