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US 6,274,623 B1Granted
Neuromuscular relaxants
AssigneeNewlaxant LLC
InventorsLaszlo Gyermek, Chingmuh Lee, Young-Moon Cho
Life of this patent
Estimating the term…
Abstract
Alkoxy and/or acyloxy disubstituted and polysubstituted aralkyl and aralkenyl bis-quaternary ammonium derivatives of cyclic alkanol diesters have neuromuscular relaxant properties.
Claims6
A compound having the formula
- where R1 and R1′ are di- or polysubstituted aralkyl or aralkenyl;
- provided that at least one substituent on each aralkyl or aralkenyl group is alkoxy or acyloxy;
- R2 and R2′ are alkyl or alkenyl;
- A is normal or substituted alkanedicarbonyl, alkenedicardonyl, alkynedicarbonyl, cycloalkanedicarbonyl, cycloalkenedicarbonyl, bicycloalkanedicarbonyl, bicycloalkenedicarbonyl, polycycloalkanedicarbonyl, polycycloalkenedicarbonyl, or aromatic dicarbonyl:
- N is 0, 1, or 2;
- m is 0, 1, or 2, p is 0, 1 or 2;
- R3 and R3′ are H, CH3, or lower alkyl;
- R4 and R4′ are H, CH3, or lower alkyl;
- R3 and R4 , together can also be -(CH2)g-, -CH=CH-, -(CH2)h-
- or —(CH2)hS—(CH2)k—, where g is 2,3,4, or 5, h is 1 or 2, and k is 1 or 2;
- and R3′ and R4′ can also be -(CH2)g-, CH=CH-, -(CH2)h-O-(CH2)k,
- or —(CH2h—S—(CH2)k—, where g is 2,3,4, or 5, h is 1 or 2, and k is 1 or 2;
- wherein R1 and R1′, R2 and R2′, R3 and R3′, R4 and R4′ can be the same or different;
- and X is a pharmaceutically acceptable anion.
11 more elements
Dependencies are inferred from the claim text.