Methods and compositions for inhibition of viral replication
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsJames W. Critchfield, Thomas M. Folks, Salvatore T. Butera, John Coligan
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Abstract
The present invention comprises methods and compositions for treating viral infection by inhibiting the activity of host cellular enzymes. More specifically, methods and compositions comprising casein kinase II inhibitors and various related compounds such as precursors, analogs, metabolites and hydrolysis products that inhibit cellular proteins and thus viral replication are provided.
Claims8
A method of treating measles virus infection in a human or animal in need thereof, comprising administering to the human or animal an effective amount of a composition comprising a compound selected from the group consisting of flavonoids, benzothiophenes, and 5,6-dichloro-1-β-D-ribofuranosylbenzinidazole (DRB), and their precursors, analogs, metabolites and hydrolysis products, wherein casein kinase II is inhibited.
A method of treating respiratory syncytial virus infection in a human or animal in need thereof, comprising administering to the human or animal, an effective amount of a composition comprising a compound selected from the group consisting of flavonoids, benzothiophenes, and 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole (DRB), and their precursors, analogs, metabolites and hydrolysis products, wherein casein kinase II is inhibited.
Dependencies are inferred from the claim text.