Heteroatom substituted benzoyl derivatives that enhance synaptic responses mediated by AMPA receptors
AssigneeThe Regents of the University of California
InventorsGary S. Lynch, Gary A. Rogers
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Abstract
Compounds are useful for enhancing synaptic responses mediated by AMPA receptors are disclosed, as are methods for the preparation thereof and methods for their use for treatment of subjects suffering from impaired nervous or intellectual functioning due to deficiencies in the number of excitatory synapses or in the number of AMPA receptors. The invention compounds can also be used for the treatment of non-impaired subjects for enhancing performance in sensory-motor and cognitive tasks which depend on brain networks utilizing AMPA receptors and for improving memory encoding.
Claims14
A compound having the general structure of Formula I:
- wherein:
- is selected from:
- —Y— is selected from:
- wherein y is 3, 4, or 5;
- and
- wherein x is 4, 5, or 6;
- —R is hydrogen or a straight chain or branched chain alkyl group having 1-6 carbon atoms;
- each —M— is independently selected from:
- —C(H)— and
- —C(Z)—, wherein Z is selected from:
- —R and —OR;
- one —Y′— is —O— and the other —Y′— is independently selected from —NR— and —N═;
- and
- —Z′— is selected from:
- —(CR2)z—, wherein z is 1, 2, or 3, and
- —Cz′R(2z-1)—, wherein z′ is 1 or 2, when one —Y′— is —N═.
A compound having the general structure of Formula II:
- wherein:
- —R is hydrogen or a straight chain or branched chain alkyl group having 1-6 carbon atoms,
- each —M— is independently selected from:
- —C(H)— and
- —C(Z)—, wherein Z is selected from:
- —R and —OR;
- one —Y′— is —O— and the other —Y′— is independently selected from —NR— and —N═;
- R′ is H or a straight or branched chain alkyl group having 1-4 carbon atoms' a is 3, 4, 5 or 6;
- b is an even number between 6-12, inclusive, depending on the value of a;
- c is 1 or 2;
- d is 0, 1 or 3.
Dependencies are inferred from the claim text.