Methods for treating antibiotic-resistant infections

A method of treating a patient suffering from infection caused by bacteria, mycobacteria or fungi by administration to said patient of a composition containing as an active agent bacteria, mycobacterium or yeast growth-inhibiting effective amount of a compound of the formula:

• wherein B is a carbon (C′) bound to an oxygen, (═O, OH, Oalk, OCOalk, OCOaryl, OCOphenyl alkyl, or an oxygen in a cyclic moiety wherein aryl is phenyl or naphthyl and alkyl has 1-4 carbons and may be substituted hydroxy, or with 1-2 halo atoms, said moeities being defined as A) and wherein said carbon C′ is also bound to a saturated carbon which is bond directly to a nitrogen-containing saturated chain or nitrogen-containing saturated ring system (for example, piperidinyl or quinuclidinyl ring systems), wherein any saturated ring system may be substituted with alkyl, alkenyl, halo, alkoxy or haloalkyl moieties of 1-5 carbons or with phenyl, phenoxy, phenylalkyl, phenylalkoxy, carboxy or carbonyl groups, wherein the carboxy or carbonyl groups, including keto or ester moieties with alkyl groups of 1-4 carbons, alkenyl groups of 2-5 carbons or phenylalkyl wherein the alkyl is of 1-3 carbons or wherein Z is R1 and/or R2 wherein at least one of R1 and R2 is an electron-rich substituent and n may be 1-4 and wherein R1 and/or R2 may be alkyl, alkoxy, aryl, aryloxy, aryloxyalkyl, amino, amino-alkyl, alkyl-aminoalkyl, arylamino, alkenyl, arylalkenyl, arylalkylaminoalkyl, carboxyalkyl, hydroxy, halo, alkenyl, alkenyloxy, herein any alkyl has 1-8 carbons, alkenyl has 2-8 carbons, wherein halo is chloro, fluoro or bromo and aryl is a ring system of 1-3 rings which may be substituted by halo, alkyl, alkoxy, alkenyl, alkenyloxy, wherein any alkyl may be subsituted with halo, amino or alkoxy.