US 6,274,585 B1 · Dihydropyrimidines and uses thereof

Abstract

This invention is directed to dihydropyrimidines which are selective antagonists for human α1a receptors. This invention is also related to uses of these compounds for relaxing lower urinary tract tissue, treating benign prostatic hyperplasia and for the treatment of any disease where the antagonism of the α1a receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

Claims29

Dependent claims

A compound having the structure:

wherein R1 is —OCH3 or OH;
wherein R2 is —CH2OH, —CH2OCH3, or —COOH;
or
wherein R1 and R2 together form a 5-membered lactone ring;
wherein R3 is selected from the group consisting of —(CH2)3OH,
or a pharmaceutically acceptable salt thereof.

3 more elements

Dependencies are inferred from the claim text.

Facts

Application

09/470,691Filed 23 Dec 1999 · us provisional application

Priority

23 Dec 1998

Granted

14 Aug 2001

Term ends

Not estimatedThe source records don’t support an estimate.

Classification5 codes

C07D 239/22
Having two double bonds between ring members or between ring members and non-ring members: with hetero atoms directly attached to ring carbon atoms
C07D 401/12
Containing two hetero rings: linked by a chain containing hetero atoms as chain links
C07D 401/14
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a…:…
C07D 491/04
In which the condensed system contains two hetero rings: ortho-condensed systems

Dihydropyrimidines and uses thereof

Life of this patent

Dihydropyrimidines and uses thereof

Life of this patent

Abstract

Claims29