Pregnane derivatives with no alpha-17 substitutent, their medicinal use, manufacturing method and its intermediaries and related compounds

A compound selected from the group consisting of a compound of formula

• wherein R1 is selected from the group consisting of halogen, —OH, alkoxy of 1 to 8 carbon atoms and acyloxy group containing 1 to 12 carbon atoms and R2 is hydrogen or halogen or R1 and R2 together form a second bond, Z is selected from the group consisting of unsubstituted or substituted alkylthio of 1 to 8 carbon atoms, unsubstituted or substituted carbocyclic aryl of 6 to 12 carbon atoms, halogen, —CH, —SH, thiocyanato, —COOA and —CH2COOA, the said substituents being at least one member of the group consisting of halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, —NH2, mono and dialkyl amino of 1 to 4 carbon atoms, —OH, acyloxy, —CN, —CF3, phenyl and —OCO—(CH2)n—COOH, n is an integer from 2 to 5, A is hydrogen or alkyl of 1 to 8 carbon atoms, Y is hydrogen or methyl, the dotted lines indicate an optional double bond and their addition salts with non-toxic, pharmaceutically acceptable acids and bases, with the provisos that when R1 and R2 form a double bond, Z is not halogen and the compound is not 9α-fluoro-16α-methyl-21-chloro-Δ1,4-pregnadiene-11β-ol-3,20-dione.