Compositions of cobalamin and related corrinoids, and uses thereof
OwnerWilliam J. Sarill, Thomas F. Brennaninventors
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Abstract
Novel compositions cobalamin and related corrinoids, and uses thereof, are disclosed. The novel compositions include a corrin, a first amino acid having a side chain which includes a basic or positively charged moiety; and a second amino acid with an uncharged side chain which includes at least one heteroatom. The compositions are useful for, inter alia, treatment of cobalamin deficiency.
Claims17
A composition comprising a mixture in a pharmaceutically acceptable carrier of:
- (a) cobalamin;
- (b) a first isolated amino acid selected from the group consisting of lysine and arginine;
- and
- (c) a second isolated amino acid selected from the group consisting of glutamine, tyrosine, serine, threonine, and asparagine, in a molar ratio of from about 1:0.1:0.1 to about 1:100:100, wherein (a), (b), and (c) are dissolved in sterile water, and wherein the amounts of (b) and (c) act in concert enhance the cellular uptake of (a) in vivo when compared to the uptake of (a) alone or the uptake of (a) in combination with casein, or (b) alone, or (c) alone.
A method of increasing cellular uptake of cobalamin in the cells of a subject, comprising administering to the subject an active amount of a composition comprising a mixture of:
- (a) cobalamin;
- (b) a first isolated amino acid selected from the group consisting of lysine and arginine;
- and
- (c) a second isolated amino acid selected from the group consisting of glutamine, tyrosine, serine, threonine, and asparagine, wherein (a), (b), and (c) are dissolved in sterile water, and wherein the amounts of (a), (b), and (c) are combined in a molar ratio of from about 1:.1:0.1, respectively, to about 1:100:100, respectively, such that the amounts of (a), (b), and (c) act in concert to increase the cellular uptake of cobalamin in the cells of the subject when compared to the uptake of cobalamin alone or the uptake of cobalamin in combination with casein, or (b) alone, or (c) alone.
Dependencies are inferred from the claim text.