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US 6,274,547 B1Granted
Methods comprising the use of human interleukin-11 receptor proteins
AssigneeGenetics Institute, Inc.
InventorJames Tobin
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Abstract
Polynucleotides encoding the human IL-11 receptor and fragments thereof are disclosed. IL-11 receptor proteins, methods for their production, inhibitors of binding of human IL-11 and its receptor and methods for their identification are also disclosed.
Claims5
A method of inhibiting binding of IL-11 to the human IL-11 receptor, said method comprising administering a composition comprising a human IL-11R receptor protein, wherein the protein comprises an amino acid sequence selected from the group consisting of:
- (a) the amino acid sequcnce of SEQ ID NO:2 from amino acid 24 to amino acid 365;
- (b) the amino acid sequence of SEQ ID NO:2 from amino acid 102 to amino acid 365;
- (c) the amino acid sequence of SEQ ID NO:2 from amino acid 24 to amino acid 359;
- (d) the amino acid sequence of SEQ ID NO:2 from amino acid 24 to amino acid 345;
- and
- (e) the amino acid sequence of SEQ ID NO:2 from amino acid 24 to amino acid 324.
3 more elements
Dependencies are inferred from the claim text.