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US 6,274,363 B1Granted
Phosphatidylcholine phospholipase D
AssigneeCell Therapeutics, Inc.
InventorsDavid W. Leung, Christopher K. Tompkins
Life of this patent
Estimating the term…
Abstract
Three new isoforms of phosphatidylcholine phospholipase D, hPLD2.1, hPLD2.2 and hPLD1.5, can be produced recombinantly and are useful for screening compounds, as drug candidates, for an ability to modify PCPLD activity.
Claims10
An isolated polynucleotide of SEQ ID NO:
- 16 (i) that codes for a human isoform of phosphatidylcholine phospholipase D, or (ii) that hybridizes under stringent conditions to a polynucleotide of SEQ ID NO:
- 16 encoding said isoform.
An isolated and purified nucleic acid sequence coding an expression for a an enzymatically active human phosphatidylchloline phospholipase D enzyme selected from the group consisting of:
- (a) a DNA sequence set forth in SEQ ID NO:
- 16 and enzymatically active fragments thereof;
- (b) a cDNA sequence which, due to the degeneracy of the genetic code, encodes a polypeptide of SEQ ID NO:
- 17 and enzymatically active fragments thereof;
- and
- (c) a cDNA sequence capable of hybridizing under high stringency conditions to a cDNA sequence encoding a polypeptide having phosphatidylchloline phospholipase D enzymatic activity.
3 more elements
Dependencies are inferred from the claim text.