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US 6,274,360 B1Granted
Conversion of compactin to pravastatin by Actinomadura
AssigneeMassachusetts Insitute of Technology
InventorsArnold L. Demain, Yulin Peng, Jacob Yashphe, Joseph Davis
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Abstract
A method for converting compactin to pravastatin is described. Compactin is provided and contacted with an agent derived from Actinomadura under conditions in which the agent converts compactin to pravastatin. Also described are an Actinomadura strain, an Actinomadura cell free extract, an Actinomadura hydroxylase, and a method for lowering cholesterol levels in mammals.
Claims7
A cell free extract derived from Actinomadura, comprising an agent that converts compactin to pravastatin.
A hydroxylase from Actinomadura that converts compactin to pravastatin,
- said hydroxylase being a constitutive enzyme;
- the activity of said hydroxylase being stimulated by any of ATP, ascorbic acid and Mg++, but not by Fe++ or Fe+++;
- and
- said hydroxylase being cytochrome P450 system-independent.
1 more element
Dependencies are inferred from the claim text.