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US 6,274,344 B1Granted
Methods for recombinant microbial production of fusion proteins and BPI-derived peptides
AssigneeXoma Corporation
InventorMarc D. Better
Life of this patent
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Abstract
The present invention relates to methods and materials for the recombinant microbial production of fusion proteins and peptides derived from or based on Domain I (amino acids 17-45), Domain II (amino acids 65-99) and Domain III (amino acids 142-169) of bactericidal/permeability-increasing protein (BPI).
Claims16
A recombinant DNA vector construct suitable for introduction into a bacterial host comprising a coding sequence for a fusion protein having:
- (a) at least one cationic bactericidal/permeability-increasing (BPI) peptide encoding DNA sequence wherein the peptide has 4-31 amino acids;
- (b) a carrier protein encoding DNA sequence;
- and (c) an amino acid cleavage site encoding DNA sequence located between the sequences (a) and (b).
Dependencies are inferred from the claim text.