Nucleic acid molecules encoding monocyte chemotactic protein 5 (MCP-5) molecules and uses therefor
AssigneeCenter for Blood Research, Inc.
InventorsJose-Carlos Gutierrez-Ramos, Gui-Quan Jia, Jose-Angel Gonzalo
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Abstract
The present invention relates to the discovery of novel genes encoding Monocyte Chemotactic Protein-5 (MCP-5) polypeptides. Therapeutics, diagnostics and screening assays based on these molecules are also disclosed.
Claims23
An isolated nucleic acid molecule which hybridizes to the complement of the nucleotide sequence of SEQ ID NO:1 or the complement of the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98172 under incubation at 45° C. in 6.0×SSC followed by washing in 0.2×SSC, 0.1% SDS at 65° C.
An isolated nucleic acid molecule comprising the nuclceoide sequence of SEQ ID NO:1 or a complement thereof.
An isolated nucleic acid molecule comprising the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98172 or a complement thereof.
An isolated nucleic acid molecule comprising the coding region of the nucleotide sequence of SEQ ID NO:1, or the coding region of the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98172 or a complement thereof.
An isolated nucleic acid molecule encoding the amino acid sequence of SEQ ID NO:2 or the amino acid sequence encoded by the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98172, or a complement thereof.
An isolated nucleic acid molecule encoding the amino acid sequence of SEQ ID NO:2 or the amino acid sequence encoded by the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98172 and heterologous amino acid sequences.
A vector comprising the coding region of the nucleotide sequence of SEQ ID NO:1 or the coding region of the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98172.
A vector comprising the nucleotide sequence of SEQ ID NO:1 or the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98172.
A host cell comprising a vector comprising the nucleotide sequence of SEQ ID NO:1 or the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98172.
An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:1.
An isolated nucleic acid molecule comprising the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98172.
An isolated nucleic acid molecule comprising the coding region of the nucleotide sequence of SEQ ID NO:1, or the coding region of the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98172.
An isolated nucleic acid molecule encoding the amino acid sequence of SEQ ID NO:2 or the amino acid sequence encoded by the nucleotide sequence of the DNA insert of the plasmid deposited with ATCC as Accession Number 98172.
Dependencies are inferred from the claim text.