Human c-Maf compositions and methods of use thereof
AssigneePresident and Fellows of Harvard College
InventorsLaurie H. Glimcher, John Douhan, III
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Abstract
Isolated nucleic acid molecules encoding human c-Maf, and isolated c-Maf proteins, are provided. The invention further provides antisense nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced and non-human transgenic animals carrying a human c-Maf transgene. The invention further provides human c-Maf fusion proteins and anti-human c-Maf antibodies. Methods of using the human c-maf compositions of the invention are also disclosed, including methods for detecting human c-Maf activity in a biological sample, methods of modulating human c-Maf activity in a cell, and methods for identifying agents that modulate the activity of human c-Maf.
Claims11
An isolated nucleic acid molecule encoding human c-Maf comprising a nucleotide sequence that encodes the polypeptide of SEQ ID NO:2.
An isolated nucleic acid molecule comprising the nucleotide sequence of the coding region of the NheI/XbaI insert of plasmid pHu-c-Maf (ATCC Accession No. 98671).
An isolated nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.