Method of treatment using recombinant human tissue plasminogen activator
AssigneeGenentech, Inc.
InventorsDavid V. Goeddel, William J. Kohr, Diane Pennica, Gordon A. Vehar
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Abstract
Human tissue plasminogen activator (t-PA) is produced in useful quantities using recombinant DNA techniques. The invention disclosed thus enables the production of t-PA free of contaminants with which it is ordinarily associated in its native cellular environment. Methods, expression vehicles and various host cells useful in its production are also disclosed.
Claims14
A method for treating a vascular disease or condition requiring thrombolytic therapy comprising administering to a subject suffering from said disease or condition an effective amount of a tissue plasminogen activator (t-PA) as produced by recombinant expression of DNA encoding said tissue plasminogen activator in transformed host cells, in admixture with a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.