Method of sequencing a nucleic acid

A method for sequencing a nucleic acid, the method comprising:

• providing one or more or more nucleic acid anchor primers linked to a solid support, wherein said solid support includes at least one optical fiber;
• providing a plurality of single-stranded circular nucleic acid templates;
• annealing an effective amount of the nucleic acid anchor primer to at least one of the single-stranded circular templates to yield a primed anchor primer-circular template complex;
• combining the primed anchor primer-circular template complex with a polymerase to generate an extended anchor primer covalently linked to a nucleic acid comprising multiple copies of a sequence complementary to the circular nucleic acid template;
• annealing an effective amount of a sequencing primer to one or more copies of said covalently linked complementary nucleic acid;
• extending the sequencing primer with a polymerase and a predetermined nucleotide triphosphate to yield a sequencing product and, if the predetermined nucleotide triphosphate is incorporated onto the 3′ end of said sequencing primer, a sequencing reaction byproduct;
• and
• identifying the sequencing reaction byproduct, thereby determining the sequence of the nucleic acid.