Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole
AssigneeByk Gulden Lomberg Chemische Fabrik GmbH
InventorsGeorge Sachs, Rango Dietrich
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Abstract
An oral pharmaceutical composition comprises an acid-labile irreversible proton pump inhibitor in pellet or tablet form, wherein the irreversible proton pump inhibitor is at least partly in slow-release form. On combined administration with an anti-microbially-active ingredient, the composition is distinguished by imparting an enhanced action of rapid onset against disorders caused by Helicobacter.
Claims17
An oral pharmaceutical composition in pellet or tablet form with delayed and controlled release of active ingredient, comprising an acid-labile irreversible proton pump inhibitor other than pantoprazole, and wherein the composition comprises an alkaline pellet or tablet core, at least one intermediate layer controlling release of active ingredient and an outer enteric layer which is soluble in the small intestine.
A process for producing an oral pharmaceutical composition in pellet or tablet form for omeprazole or lansoprazole, as active ingredient, which comprises a) incorporating the active ingredient as an alkaline salt and/or with addition of an alkaline substance in a pellet or tablet core, b) applying thereto at least one release-slowing intermediate layer comprising a water-insoluble, release-slowing film former and c) subsequently applying an outer enteric layer which is soluble in the small intestine.
An oral pharmaceutical composition in pellet or tablet form with delayed and controlled release of active ingredient and comprising an acid-labile irreversible proton pump inhibitor other than pantoprazole, and wherein part of the proton pump inhibitor is in a controlled (extended) release form and part of the proton pump inhibitor is in a form without retarding its release (rapid release form).
An oral pharmaceutical composition in pellet or tablet form comprising an acid-labile irreversible proton pump inhibitor and having an alkaline pellet or tablet core, at least one release-slowing, release-controlling intermediate layer and an outer enteric layer which is soluble in the small intestine, wherein the intermediate layer comprises a water-insoluble film former.
Dependencies are inferred from the claim text.