Therapeutic effervescent compositions
AssigneeSmithKline Beecham Laboratoires Pharmaceutiques
InventorJacky Andre Gustave Mention
Life of this patent
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Abstract
Granulates comprising an effervescent couple of anhydrous powdered monosodium citrate and powdered sodium bicarbonate and prepared using a roller compactor are formulated into pharmaceutical compositions.
Claims21
A process for preparing pharmaceutical granulates comprising an effervescent couple which process comprises the steps of:
- a) blending together the components of the couple, which are anhydrous powdered monosodium citrate and powdered sodium bicarbonate;
- b) roller compacting the blend to produce flakes;
- c) crushing the flakes to obtain granulates;
- and
- d) if necessary and so desired, screening the granulates by size.
A pharmaceutical formulation comprising granulates which comprise an effervescent couple, and a drug substance incorporated into the granulates, in which the couple comprises anhydrous powdered monosodium citrate and powdered sodium bicarbonate;
- and wherein the drug substance is cimetidine, or the hydrochloride salt thereof, or paracetamol, and wherein the granulates are prepared using a roller compactor.
A process for preparing pharmaceutical granulates which granulates comprising an effervescent couple and a drug substance, and wherein the couple comprises anhydrous powdered monosodium citrate, and powdered sodium bicarbonate, which process comprises the steps of:
- a) blending together the components of the couple;
- b) roller compacting the blend to produce flakes;
- c) crushing the flakes to obtain granulates;
- and
- d) if necessary and so desired, screening the granulates by size;
- e) adding to the flakes of step (c) or (d) a drug substance.
Dependencies are inferred from the claim text.