Compounds for cardiovascular treatment comprising multi-vitamin and anti-platelet aggregating agents and methods for making and using the same
OwnerRichard Heibel, John J. Abbottinventors
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Abstract
Compounds comprising multi-vitamins, zinc and an anti-platelet aggregating agent for the treatment of atherosclerotic cardiovascular disease (ASCVD) are disclosed. The compounds are provided in dosage form, and preferably include selected amounts of ascorbic acid, folic acid, vitamin E, vitamin B6 and vitamin B12. The anti-platelet aggregating agent preferably comprises aspirin. A protective coating is preferably provided between the aspirin and the other vitamin and mineral constituents. The dosages are effective in the treatment of ASCVD, and possess extended shelf lives.
Claims64
A compound dosage for the treatment of atherosclerotic cardiovascular disease comprising:
- ascorbic acid, folic acid, a minimum of about 200 International Units of vitamin E, vitamin B6 and vitamin B12 in therapeutic amounts effective for the treatment of atherosclerotic cardiovascular disease;
- zinc;
- and
- an anti-platelet aggregating agent.
A compound dosage for the treatment of atherosclerotic cardiovascular disease comprising:
- at least two vitamins selected from the group consisting of ascorbic acid, folic acid, vitamin E, vitamin B6 and vitamin B12;
- zinc;
- an anti-platelet aggregating agent;
- and
- a protective coating between the anti-platelet aggregating agent and the vitamins and zinc.
A method of making a compound dosage for the treatment of atherosclerotic cardiovascular disease, the method comprising the steps of:
- providing ascorbic acid, folic acid, a minimum of about 200 International Units of vitamin E, vitamin B6 and vitamin B12 in therapeutic amounts effective for the treatment of atherosclerotic cardiovascular disease;
- providing zinc;
- and
- combining the ascorbic acid, folic acid, vitamin E, vitamin B6, vitamin B12 and zinc with an anti-platelet aggregating agent in dosage form.
A method of making a compound dosage for the treatment of atherosclerotic cardiovascular disease, the method comprising the steps of:
- providing at least two vitamins selected from the group consisting of ascorbic acid, folic acid, vitamin E, vitamin B6 and vitamin B12;
- providing zinc;
- combining the vitamins and zinc with an anti-platelet aggregating agent in dosage form;
- and
- providing a protective coating between the anti-platelet aggregating agent and the vitamins and zinc.
A method of treating a patient having atherosclerotic cardiovascular disease, the method comprising administering an effective amount of a compound dosage to the patient, the compound dosage comprising:
- ascorbic acid, folic acid, a minimum of about 200 International Units of vitamin E, vitamin B6 and vitamin B12 in therapeutic amounts effective for the treatment of atherosclerotic cardiovascular disease;
- zinc;
- and
- an anti-platelet aggregating agent.
A method of treating a patient having atherosclerotic cardiovascular disease, the method comprising administering an effective amount of a compound dosage to the patient, the compound dosage comprising:
- at least two vitamins selected from the group consisting of ascorbic acid, folic acid, vitamin E, vitamin B6 and vitamin B12;
- zinc;
- an anti-platelet aggregating agent;
- and
- a protective coating between the anti-platelet aggregating agent and the vitamins and zinc.
A compound dosage for the treatment of atherosclerotic cardiovascular disease comprising:
- ascorbic acid, folic acid, vitamin B6, vitamin B12, and a minimum of about 200 International Units of vitamin E;
- zinc;
- and
- an anti-platelet aggregating agent.
A method of making a compound dosage for the treatment of atherosclerotic cardiovascular disease, the method comprising the steps of:
- providing ascorbic acid, folic acid, vitamin B6, vitamin B12, and a minimum of about 200 International Units of vitamin E;
- providing zinc;
- and
- combining the ascorbic acid, folic acid, vitamin B6, vitamin B12, vitamin E and zinc with an anti-platelet aggregating agent in dosage form.
A method of treating a patient having atherosclerotic cardiovascular disease, the method comprising administering an effective amount of a compound dosage to the patient, the compound dosage comprising:
- ascorbic acid folic acid, vitamin B6, vitamin B12, and a minimum of about 200 International Units of vitamin E;
- zinc;
- and
- an anti-platelet aggregating agent.
A compound dosage for the treatment of atherosclerotic cardiovascular disease comprising:
- ascorbic acid, folic acid, vitamin E, vitamin B6 and vitamin B12;
- zinc;
- and
- an anti-platelet aggregating agent selected from the group consisting of ibuprofen, flubiprofen, ketoprofen, naproxen, tolmetin, fenoprofen, piroxicam, sulindac and mefenamic acid.
A method of making a compound dosage for the treatment of atherosclerotic cardiovascular disease, the method comprising the steps of:
- providing ascorbic acid, folic acid, vitamin E, vitamin B6 and vitamin B12;
- providing zinc;
- and
- combining in dosage form the ascorbic acid, folic acid, vitamin E, vitamin B6, vitamin B12 and zinc with an anti-platelet aggregating agent comprising at least one agent selected from the group consisting of ibuprofen, flubiprofen, ketoprofen, naproxen, tolmetin, fenoprofen, piroxicam, sulindac and mefenamic acid.
A method of treating a patient having atherosclerotic cardiovascular disease, the method comprising administering an effective amount of a compound dosage to the patient, the compound dosage comprising:
- ascorbic acid, folic acid, vitamin E, vitamin B6 and vitamin B12;
- zinc;
- and
- an anti-platelet aggregating agent comprising at least one agent selected from the group consisting of ibuprofen, flubiprofen, ketoprofen, naproxen, tolmetin, fenoprofen, piroxicam, sulindac and mefenamic acid.
Dependencies are inferred from the claim text.