Transdermal, hormone-delivering therapeutic system
AssigneeLTS Lohmann Therapie-Systeme AG
InventorsReinhold Meconi, Frank Seibertz
Life of this patent
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Abstract
An active compound-containing patch for the controlled delivery of oestradiol or its pharmaceutically acceptable derivatives, alone or in combination with gestagens, to human or animal skin, having an active compound-containing reservoir based on ethylcellulose and contact adhesives comprising adhesive resins is characterized by a contact adhesive having a high plasticizer content.
Claims17
Active compound-containing patch for the controlled delivery of oestradiol or its pharmaceutically acceptable derivatives alone or in combination with gestagen to human or animal skin consisting essentially of an active compound-containing reservoir based on ethylcellulose and contact adhesives wherein the contact adhesive has a proportion of plasticizer of at least 15% by weight.
An active compound-containing patch for the controlled delivery of oestradiol or its pharmaceutically acceptable derivatives alone or in combination to human or animal skin comprising:
- 5-25% by weight of ethylcellulose
- 10-70% by weight of tackifying resin
- 20-40% by weight of plasticizer and emulsifiers
- 1-10% by weight of oestradiol content
- 1-15% by weight of gestagen.
Active compound-containing patch for the controlled delivery of estradiol or its pharmaceutically acceptable derivatives alone or in combination with gestagen to human or animal skin consisting of:
- (a) an active compound-containing reservoir based on ethyl cellulose;
- (b) contact adhesive wherein the contact adhesive has a proportion of plasticizer of at least 15% by weight;
- (c) esters of optionally hydrogenated colophony as a tackifying resin;
- (d) a content of absorption enhancers;
- and
- (e) a content of antioxidants.
The active compound patch for the controlled delivery of estradiol or its pharmaceutically acceptable derivatives alone or in combination with gestagen to human or animal skin consisting essentially of:
- (a) an active compound-containing reservoir based on ethyl cellulose;
- (b) contact adhesives wherein the contact adhesive has a proportion of plasticizer of at least 15% by weight and an emulsifier content of at least 15% by weight,
- (c) esters of optionally hydrogenated colophony as a tackifying resin;
- (d) a content of absorption enhancers;
- and
- (e) a content of antioxidants and specifically excluding N-substituted o-toluidines.
Dependencies are inferred from the claim text.