Methods of neutralizing coagulation with anti-tissue factor antibodies
AssigneeGenentech, Inc.
InventorsDonogh P. O'Brien, Gordon A. Vehar
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Abstract
The present invention relates to a method and therapeutic composition for the treatment of myocardial infarction comprising administration of a tissue factor protein antagonist and a thrombolytic agent. In addition, the present invention relates to methods of neutralizing coagulation, including in patients with deep vein thrombosis, with anti-tissue factor antibodies.
Claims6
A method of neutralizing the coagulant activity of tissue factor in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an antibody which binds to tissue factor protein and neutralizes the coagulant activity of tissue factor.
A method of treating a coagulation disorder in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an antibody which binds to tissue factor protein such that the tissue factor protein cannot bind to factor VIIa.
Dependencies are inferred from the claim text.