Back to results
US 6,274,139 B1Granted
Topoisomerase I
AssigneeSmithKline Beecham Corporation
InventorsMichael N. Gwynn, Howard Kallendar, Leslie M. Palmer
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeSmithKline Beecham Corporation
InventorsMichael N. Gwynn, Howard Kallendar, Leslie M. Palmer
Estimating the term…
Topoisomerase I polypeptides and DNA and RNA encoding such Topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase I and for detecting the polypeptide in a host.
An isolated protein comprising a polypeptide, wherein the polypeptide comprises an amino acid sequence which is identical to SEQ ID NO:2 except that, over the entire length corresponding to SEQ ID NO:2, there are five to ten point mutations, wherein each point mutation is the substitution, deletion or insertion of one amino acid.
An isolated protein comprising a polypeptide, wherein the polypeptide comprises a amino acid sequence which is identical to SEQ ID NO:2 except that, over the entire length corresponding to SEQ ID NO:2, there are one to five point mutations, wherein each point mutation is the substitution, deletion or insertion of one amino acid.
An isolated protein comprising the amino acid sequence set forth in SEQ ID NO:2.
An isolated fusion protein comprising a heterologous amino acid sequence used to the amino acid sequence set forth in SEQ ID NO:2.
An isolated protein comprising at least 50 consecutive amino acids of SEQ ID NO:2.
An isolated protein comprising at least 3 consecutive amino acids of SEQ ID NO:2.
Dependencies are inferred from the claim text.