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US 6,274,117 B1Granted
Cytokines that bind the cell surface receptor Hek
AssigneeImmunex Corporation
InventorsM. Patricia Beckmann, Douglas P. Cerretti
Life of this patent
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Abstract
Hek ligand (hek-L) polypeptides as well as DNA sequences, vectors and transformed host cells useful in providing hek-L polypeptides. The hek-L polypeptides bind to a cell surface receptor (hek) that is a member of the receptor tyrosine kinase family. Hek is expressed on cells that include certain tumor cell lines. The hek-L polypeptides also bind a distinct receptor tyrosine kinase known elk.
Claims7
A conjugate comprising a diagnostic or therapeutic agent and a hek-L polypeptide, wherein said hek-L polypeptide is selected from the group consisting of:
- a) the hek-L protein of SEQ ID NO:2 in mature form;
- b) a fragment of the hek-L protein of SEQ ID NO:2;
- c) the hek-L protein of SEQ ID NO:4 in mature form;
- and
- d) a fragment of the hek-L protein of SEQ ID NO:4;
- wherein said fragment binds hek.
3 more elements
Dependencies are inferred from the claim text.