Compositions for boron delivery to mammalian tissue
AssigneeThe Reagents of the University of California
InventorsM. Frederick Hawthorne, Debra Arlene Feaks, Kenneth John Shelly
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Abstract
Boron neutron capture therapy can utilize XyB20H17L where X is an alkali metal, y is 1 to 4, and L is a two electron donor such as NH3, and Na2B10H9NCO, among others. These borane salts may be used free or encapsulated in liposomes. Liposomes may also have embedded within their bilayers carboranes to increase the amount of delivered 10B and/or to increase the tumor specificity of the liposome.
Claims24
A liposome having one or more encapsulating bilayers and an internal space defined by the encapsulating bilayer wherein a carborane is emdedded in the bilayer of the liposome.
Dependencies are inferred from the claim text.