Medical devices having improved antimicrobial/antithrombogenic properties

A medical device comprising a non-conductive plasticized polymer body, said polymer body comprising at least one iontophoretic compound, said polymer body further comprising an ionophore selected from the group consisting of metal ionophores, halide ionophores, proton ionophores and electron ionophores, and wherein:

• said polymer body comprises a surface and a polymer matrix located within said polymer body under said surface, wherein at least a portion of the iontophoretic compound is exposed iontophoretic compound which is located at said surface and wherein at least a portion of the iontophoretic compound is unexposed iontophoretic compound which is also located at said surface but within said polymer matrix, said iontophoretic compound further including unexposed iontophoretic compound located deeper within said polymer matrix, wherein the medical device is made by:
• treating said polymer body with a sufficient amount of an exposure enhancing reagent for a sufficient time to expose at least a portion of the unexposed iontophoretic compound located within said polymer body surface and/or polymer matrix.

A medical device comprising a non-conductive highly plasticized polymer body, said polymer body comprising at least one iontophoretic compound, said polymer body further comprising a conductive polymer wherein said polymer body has a glass transition temperature between ambient and body temperature.